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4-Hydroxybenzyl alcohol

CAS No. 623-05-2

4-Hydroxybenzyl alcohol ( —— )

产品货号. M18916 CAS No. 623-05-2

4-Hydroxybenzylool 在脑缺血性损伤中表现出有益作用,通过 PI3K/Akt 途径上调 Nrf2、Prdx6 和 PDI 表达而具有神经保护作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG ¥235 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    4-Hydroxybenzyl alcohol
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    4-Hydroxybenzylool 在脑缺血性损伤中表现出有益作用,通过 PI3K/Akt 途径上调 Nrf2、Prdx6 和 PDI 表达而具有神经保护作用。
  • 产品描述
    4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway. 4-Hydroxybenzyl alcohol inhibit the development of new blood vessels by targeting multiple mechanisms of the angiogenic process, may as a promising candidate for the establishment of anti-angiogenic treatment strategies in cancer therapy.
  • 体外实验
    4-Hydroxybenzyl alcohol inhibits proliferation of eEND2 cells and suppresses the migration of eEND2 cells, accompanied by inhibition of actin filament reorganization.4-Hydroxybenzyl alcohol induces apoptotic death of tumor cells.
  • 体内实验
    4-Hydroxybenzyl alcohol possesses antiangiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production. 4-Hydroxybenzyl alcohol (200 mg/kg) efficiently inhibits growth and angiogenesis of developing tumors.4-Hydroxybenzyl alcohol ameliorates ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect may be partly related to attenuate apoptosis pathway.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Others-Field
  • 适应症
    ——

化学信息

  • CAS Number
    623-05-2
  • 分子量
    124.14
  • 分子式
    C7H8O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 100 mg/mL; 805.54 mM
  • SMILES
    C1=CC(=CC=C1CO)O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Laschke MW,et al.4-hydroxybenzyl alcohol: a novel inhibitor of tumor angiogenesis and growth. 2013 Jul 19;93(1):44-50.
产品手册
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